Contacts: F. Arefi-Khonsari, J. Pulpytel
Recently we have developed in the framework of Plan Cancer – INSERM, Project ID PC201404) CORAPLAS (Controlled Release of Antineoplastic Drug from Low and Atmospheric Pressure Plasma Polymerized Biodegradable Coatings for Oncological Applications), a drug delivery device in the form of patches from the plasma copolymerization of polycaprolactone-polyethylene-glycol (PCL-PEG) with the incorporation of carboplatin in a sandwich structure of copolymers. The leaching out of carboplatin up to 1000h has been measured in vitro, and the cytotoxicity of the drug delivery device has been measured in-vivo on 24 BALB mice which have developed inguinal lymphatic tumors.
[1] A. Baitukha, I. Al-Dybiat, A. Valinataj-Omran, J. Pulpytel, M. Pocard, M. Mirshahi and F. Arefi-Khonsari, Low Pressure Plasma Processing of Collagen Membranes for Anti-Cancer Drug Delivery, J Material Sci Eng.2018, 7:6 DOI: 10.4172/2169-0022.100
[2] A. Baitukha, I. Al-Dybiat, A. Valinataj-Omran, J. Pulpytel, M. Pocard, M. Mirshahi, F. Arefi-Khonsari, Optimization of a low pressure plasma process for fabrication of a Drug T Delivery System (DDS) for cancer treatment, Materials Science & Engineering C 105(2019)
Multilayer copolymers deposited on the biocompatible collagen substrate